SBML-SAT is a Systems Biology Markup Language (SBML) based Sensitivity Analysis Tool. This tool is designed to implement a variety of simulation, steady state analysis, sensitivity analysis and robustness analysis for ordinary differential equations (ODE) based biological models including biophysical models, signaling pathways, gene regulation networks and metabolic pathways.

SBML-SAT supports import of models in the System Biology Mark-up Language (SBML) format. SBML-SAT can run on Windows, Linux and Mac with Matlab. Current versions of SBML-SAT support SBML in level 2 version 1 (or earlier levels). Next release will support new levels of SBML.

Features of SBML-SAT

    •  Supports SBML

    •  Supports events

    •  Time course simulation

    •  Local sensitivity analysis

    •  Global sensitivity analysis

        (1) Multi-Parametric Sensitivity Analysis
        (2) Partial Rank Correlation Coefficient Analysis
        (3) SOBOL's Method (Current SBML-SAT might have a potential bug for the implementation of this method.)
        (4) Weighted Average of Local Sensitivities

    •  Steady state analysis

    •  Robustness analysis